Learning January 06, 2020

Formula 4|5: the deets.

MIGHTY Menopause Formula 4|5 is like no other natural supplement on the market today. Formula 4|5 is designed specifically for the hormonal profile of perimenopause, which is distinct from other phases of the multi-year transition of menopause. And typically marked the by the onset of symptoms (i.e., there is no standard test for perimenopause). 

According to a meta study encompassing decades of perimenopause clinical research, during perimenopause, estrogen levels are on average higher than during the reproductive years and are also highly volatile. In contrast, the prevailing understanding is that menopause is a state of estrogen deficiency which is technically accurate but not applicable throughout the entire years long transition. Most supplements available currently for menopause-related symptoms presume estrogen deficiency as the root cause of symptoms. They are designed for estrogen supplementation with herbs that are estrogenic or promote estrogenic activity.

This is the opposite of what women need during perimenopause. The abundance of estrogen is the root cause of the more prominent symptoms, very heavy bleeding and emotional volatility (commonly, high anxiety) and more estrogenic or estrogen-like effect would likely make symptoms worse. Additionally, progesterone production wanes causing shortened cycles and increased PMS symptoms (both common complaints). The ideal remedy would be to get rid of estrogen and boost progesterone.

MIGHTY Menopause understands this and created Formula 4|5 based on the specific hormonal changes at perimenopause and to address the root causes underlying the symptoms. It also includes a trademarked blend showing clinical efficacy across multiple menopause-related symptoms. Because, symptoms are complex and variable and manifest in different ways for different women.
Formula 4|5 combines its own MIGTHY Proprietary Blend with two trademarked natural supplements EstroG-100™ and BioPerine™.

MIGHTY Proprietary Blend

>> Vitex Angus Castus (Chasteberry) has a long history of treating gynecological conditions commonly used during perimenopause to stimulate progesterone production.  Also has shown efficacy in relieving hot flashes.
>> Indole-3-carbinole (I3C) is a phytochemical found in cruciferous vegetables, like broccoli, cauliflower, brussels sprouts and kale. Clinical research shows that it improves estrogen metabolism. 
>> DIM (diindolylmethane) is a metabolite of I3C and has shown to help metabolize estrogen.
>> Milk Thistle is widely used to promote liver health which can help process excess estrogen and its metabolites.
>> EstroG-100™ is a proprietary blend of three botanicals (Cynanchum wilfordii, Phlomis umbrosa and Angelica gigas) with a 400-year history of use in China and Korea. It has proven clinical efficacy across a multitude of menopause symptoms, no side effects (weight gain), no estrogenic effects (increased uterine weight, no binding to ERa or ERb); tested on pre, peri and post-menopausal women.
BioPerine™ is a black pepper extract widely known to increase bioavailability.

Key highlights of Formula 4|5:

>> This formula does not exist in the market today. Designed specifically for perimenopause hormonal profile of high estrogen, low progesterone

>> All ingredients clinically proven to improve symptoms

>> Convenient + effective. All ingredients available in the market currently but not combined in a single formula

>> It is designed to address the multi-symptomatic state of perimenopause because symptoms don’t come alone. Many women have multiple symptoms (not just one – though one may be more dominant than others). Foundational ingredient, EstroG-100™, positively impact scores on multiple symptoms

 >> No estrogenic effects from these plants (concerns about cancer – breast cancer, especially due to excess of a certain type of estrogen activity)

>> Modern and stylish branding differentiating it from the old-fashioned branding of existing products. 

    For the geeky side of you, select clinical research:

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